BIOACTIVITY TESTING SERVICES

Fast, reliable and inexpensive pre-clinical claim validation for cosmeceutical
products before you start spending heavily on clinical studies.


We specialize in custom tests and method development for:


* Scientific validation of bioactivity claims

* Testing of active materials for new bioactivity

* Development of new cosmetic claim concepts backed by
scientific publications (see "
Science" page)
Sunny BioDiscovery, Inc.
Welcome!
Highlights:

Over 20 standard tests for skin-relevant bioactivities (collagen
and hyaluronic acid stimulation, antioxidant activity, inhibition of
MMPs, inflammation and Advenced Glycation Endproducts…)

Tests on Cell Cultures and Skin Substitutes (penetration,
whitening, irritation…)

PCR arrays and DNA microarrays (Anti-aging, anti-inflammation,
skin structure, wound healing, and more)

Phototoxicity, viability, human dermal fibroblast & keratinocyte
proliferation assays

HPLC, LC-MS, Fluorometry, TLC, Spectrophotometry, skin
oxygenation

Selected test examples:





































Located among the orchards of Santa Paula (Ventura county, Southern CA),
Sunny BioDiscovery, Inc. has been in the Research & Development business
for over 15 years and our science has been honored by several NIH grants,
including from the National Institute on Aging and National Cancer Institute.

We have worked with many publicly and privately held companies, enabling
them to validate the bioactive potential of their ingredients. You can entrust
your materials to us for a fast, precise and professional service.

At Sunny BioDiscovery, your materials will be custom-tested under the
supervision of an experienced PhD or MD scientist, who will then prepare a
written report and will be available for discussing the results over the phone.  
We guarantee the quality and the confidentiality of our services.
Test
Approximate
turn-around
Potential for angiogenesis modulation
(endothelial cell growth) Test # 01

2 weeks
In vitro angiogenesis modulation
(tube formation on matrigel ) Test #
02        

2-3 weeks
In vitro angiogenesis modulation
(tridimensional tube network) Test #
03

5-7 weeks
Collagen Production (human dermal
fibroblasts) Test # 04

2-4 weeks
Elastase Inhibition Test # 05
2-4 weeks
Fibroblast ProliferationTest # 06
2-4 weeks
Keratinocyte ProliferationTest # 07
2-4 weeks
Matrix Metalloproteinase (MMP)
Inhibition Test # 08
2-4 weeks
Lipolysis on mouse and human
adipocytes Test # 09A and 09B
2-4 weeks
Superoxide Desmutase Stimulation
Test # 10
2-4 weeks
UV-induced Lipid Peroxidation Test #
11
2-4 weeks
3T3 NRU Phototoxicity Test #12
2 weeks
Mitochondrial Metabolism Test # 13
2-4 weeks
PCR array screen of expression of any
genes of interest Test # 14
4-6 weeks
Skin irritation on EpiDerm(TM) and
ocular iritation on EpiOcular(TM)
Test#15A and 15B
2-4 weeks
Percutaneous absorption on
EpiDerm(TM) Test #1 6
4-6 weeks
Effect on B16 (skin) and MDA MD435
(breast)cancer cell lines Test # 17
2 weeks
Tyrosinase Inhibition Test # 18
2-4 weeks
Melanocyte Pigmentation Test # 19
2-4 weeks
Anti-glycation (AGE) Test # 20
4 weeks
ORAC, DPPH, DCFH (anti-oxidant)
Test # 21OR/DP/DC
1 week
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