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Fast, reliable and inexpensive pre-clinical claim validation for cosmeceutical products before you start spending heavily on clinical studies. Located among the orchards of Santa Paula (Ventura county, Southern CA), Sunny BioDiscovery, Inc. has been in the Research & Development business for over 20 years and our science has been honored by several NIH grants, including from the National Institute on Aging and National Cancer Institute.


We have worked with many publicly and privately held companies, enabling them to validate the bioactive potential of their ingredients. You can entrust your materials to us for a fast, precise and professional service. At Sunny BioDiscovery, your compounds will be custom-tested under the supervision of an experienced PhD or MD scientist, who will then prepare a written report and will be available for discussing the results over the phone. We guarantee the quality and the confidentiality of our services.

We specialize in custom tests and method development for:

Scientific validation of bioactivity claims

Testing of active materials for new bioactivities

Development of new cosmetic claim concepts backed by scientific publications (see "Science" page)

Highlights

Intradermal, transdermal and trans stratum corneum permeation (Strat M and PAMPA models)

Over 30 standard tests for skin-relevant bioactivities (eg. collagen and hyaluronic acid stimulation, antioxidant activity, inhibition of MMPs, inflammation, Advenced Glycation Endproducts…)

Tests on Cell Cultures, Skin Substitutes and human skin biopsies [inhibition of senescence, mitophagy, whitening, irritation, skin penetration, proteins of skin barrier and extracellular matrix (ECM)…]

Transcriptome Analysis: PCR arrays, RNA-seq, DNA microarrays (Anti-aging, anti-inflammation, skin structure, wound healing, and more)

Phototoxicity, cell & skin viability, human dermal fibroblast & keratinocyte proliferation assays, reporter assays for transcriptional regulation by retinoic acid nuclear receptors, PPARs and other transcription factors.

HPLC, LC-MS, Fluorometry, TLC, Spectrophotometry, Chemoluminescence, Cell Imaging, Skin Oxygenation

Selected Test Examples Turn-Around
Potential for angiogenesis modulation (endothelial cell growth) Test # 01 2 weeks
In vitro angiogenesis modulation, tube formation on matrigel Test # 02 2-3 weeks
In vitro angiogenesis modulation (tridimensional tube network) Test # 03 5-7 weeks
Collagen and other ECM component Production (by ELISA on human dermal fibroblasts) Test # 04 2-4 weeks
Elastase Inhibition Test # 05 2-4 weeks
Fibroblast ProliferationTest # 06 2-4 weeks
Keratinocyte ProliferationTest # 07 2-4 weeks
Matrix Metalloproteinase (MMP) Inhibition Test # 08 2-4 weeks
Lipolysis on mouse and human adipocytes Test # 09A and 09B 2-4 weeks
Superoxide Desmutase Stimulation Test # 10 2-4 weeks
UV-induced Lipid Peroxidation Test # 11 2-4 weeks
3T3 NRU Phototoxicity Test #12 2 weeks
Mitochondrial Metabolism Test # 13 2-4 weeks
PCR array screen of expression of any genes of interest Test # 14 4-6 weeks
Skin irritation on EpiDerm(TM) and ocular iritation on EpiOcular(TM) Test#15A and 15B 2-4 weeks
Percutaneous absorption on EpiDerm(TM) Test #1 6 4-6 weeks
Effect on B16 melanoma, PANC-1 and MDA MD435 (breast) cancer cell lines Test # 17 2 weeks
Tyrosinase Inhibition Test # 18 2-4 weeks
Melanocyte Pigmentation Test # 19 2-4 weeks
Anti-glycation (AGE) Test # 20 4 weeks
ORAC, DPPH, DCFH (anti-oxidant) Test # 21OR/DP/DC 1 week

HPLC

Immunocyto- & Histochemistry

ELISA & Cell-Based Assays

Inflammation & Atopic Dermatitis Models

Human Skin Explant-Based Studies

RNA Isolation for qPCR and RNA-seq

Let's Get In Touch!

For more information or to contact us, call us at (805) 229 7580 or fill out the form below. Thank you!

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