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Fast, reliable and inexpensive pre-clinical claim validation for cosmeceutical products before you start spending heavily on clinical studies. Located among the orchards of Santa Paula (Ventura county, Southern CA), Sunny BioDiscovery, Inc. has been in the Research & Development business for over 20 years and our science has been honored by several NIH grants, including from the National Institute on Aging and National Cancer Institute.
We have worked with many publicly and privately held companies, enabling them to validate the bioactive potential of their ingredients. You can entrust your materials to us for a fast, precise and professional service. At Sunny BioDiscovery, your compounds will be custom-tested under the supervision of an experienced PhD or MD scientist, who will then prepare a written report and will be available for discussing the results over the phone. We guarantee the quality and the confidentiality of our services.
Scientific validation of bioactivity claims
Testing of active materials for new bioactivities
Development of new cosmetic claim concepts backed by scientific publications (see "Science" page)
Intradermal, transdermal and trans
stratum corneum permeation (Strat M and PAMPA models)
Over 30 standard tests for skin-relevant bioactivities (eg. collagen and hyaluronic acid stimulation, antioxidant activity, inhibition of MMPs, inflammation, Advenced Glycation Endproducts…)
Tests on Cell Cultures, Skin Substitutes and human skin biopsies [inhibition of senescence, mitophagy, whitening, irritation, skin penetration, proteins of skin barrier and extracellular matrix (ECM)…]
Transcriptome Analysis: PCR arrays, RNA-seq, DNA microarrays (Anti-aging, anti-inflammation, skin structure, wound healing, and more)
Phototoxicity, cell & skin viability, human dermal fibroblast & keratinocyte proliferation assays, reporter assays for transcriptional regulation by retinoic acid nuclear receptors, PPARs and other transcription factors.
HPLC, LC-MS, Fluorometry, TLC, Spectrophotometry, Chemoluminescence, Cell Imaging, Skin Oxygenation
Selected Test Examples | Turn-Around |
---|---|
Potential for angiogenesis modulation (endothelial cell growth) Test # 01 | 2 weeks |
In vitro angiogenesis modulation, tube formation on matrigel Test # 02 | 2-3 weeks |
In vitro angiogenesis modulation (tridimensional tube network) Test # 03 | 5-7 weeks |
Collagen and other ECM component Production (by ELISA on human dermal fibroblasts) Test # 04 | 2-4 weeks |
Elastase Inhibition Test # 05 | 2-4 weeks |
Fibroblast ProliferationTest # 06 | 2-4 weeks |
Keratinocyte ProliferationTest # 07 | 2-4 weeks |
Matrix Metalloproteinase (MMP) Inhibition Test # 08 | 2-4 weeks |
Lipolysis on mouse and human adipocytes Test # 09A and 09B | 2-4 weeks |
Superoxide Desmutase Stimulation Test # 10 | 2-4 weeks |
UV-induced Lipid Peroxidation Test # 11 | 2-4 weeks |
3T3 NRU Phototoxicity Test #12 | 2 weeks |
Mitochondrial Metabolism Test # 13 | 2-4 weeks |
PCR array screen of expression of any genes of interest Test # 14 | 4-6 weeks |
Skin irritation on EpiDerm(TM) and ocular iritation on EpiOcular(TM) Test#15A and 15B | 2-4 weeks |
Percutaneous absorption on EpiDerm(TM) Test #1 6 | 4-6 weeks |
Effect on B16 melanoma, PANC-1 and MDA MD435 (breast) cancer cell lines Test # 17 | 2 weeks |
Tyrosinase Inhibition Test # 18 | 2-4 weeks |
Melanocyte Pigmentation Test # 19 | 2-4 weeks |
Anti-glycation (AGE) Test # 20 | 4 weeks |
ORAC, DPPH, DCFH (anti-oxidant) Test # 21OR/DP/DC | 1 week |
HPLC
Immunocyto- & Histochemistry
ELISA & Cell-Based Assays
Inflammation & Atopic Dermatitis Models
Human Skin Explant-Based Studies
RNA Isolation for qPCR and RNA-seq
For more information or to contact us, call us at (805) 229 7580 or fill out the form below. Thank you!
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